As Iran retaliates, largest US military base in Middle East hit by ballistic missile, Qatar says

No one was injured, according to the Qatari Ministry of Defense.

President Donald Trump announced "major combat operations" against Iran on Saturday, with daytime strikes in the joint U.S.-Israel attack targeting military and government sites, officials said.

On Sunday, Iranian state television confirmed that Ayatollah Ali Khamenei was among those killed by airstrikes in Tehran on Saturday.

Iran is responding to the U.S.-Israeli operation with missile and drone attacks targeting Israel, regional U.S. bases and Gulf nations. American diplomatic facilities have also been attacked.

In Lebanon, Israel is intensifying its long-running strike campaign against the Iranian-aligned Hezbollah militia.

Watch special coverage on Nightline, "War with Iran," each night on ABC and streaming on Disney+ and Hulu.

Feb 28, 2026, 2:50 AM EST

Trump says 'lives of courageous American heroes may be lost' in Iran strike

President Donald Trump said that "the lives of courageous American heroes may be lost and we may have casualties," in a video post on Truth Social early Saturday morning.

"That often happens in war. But we are doing this not for now, we are doing this for the future and it is a noble mission," Trump continued.

Feb 28, 2026, 2:50 AM EST

Trump cites 'imminent threats' from Iran

In his address, President Donald Trump said: "Our objective is to defend the American people by eliminating imminent threats from the Iranian regime, a vicious group of very hard, terrible people."

Feb 28, 2026, 2:42 AM EST

Trump confirms 'major combat operations in Iran'

President Donald Trump confirmed the U.S. military began "major combat operations in Iran," in a video posted on his social media platform.

Feb 28, 2026, 2:22 AM EST

'US strikes are in progress': Official

Israel and the U.S. have launched a joint attack on Iran, according to two U.S. officials.

The attacks have begun and they are being described as not small-scale, according to one U.S. official.

A plume of smoke rises after an explosion on February 28, 2026 in Tehran, Iran.
Getty Images

-ABC News' Luis Martinez and Anne Flaherty

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