No one was injured, according to the Qatari Ministry of Defense.
President Donald Trump announced "major combat operations" against Iran on Saturday, with daytime strikes in the joint U.S.-Israel attack targeting military and government sites, officials said.
On Sunday, Iranian state television confirmed that Ayatollah Ali Khamenei was among those killed by airstrikes in Tehran on Saturday.
Iran is responding to the U.S.-Israeli operation with missile and drone attacks targeting Israel, regional U.S. bases and Gulf nations. American diplomatic facilities have also been attacked.
In Lebanon, Israel is intensifying its long-running strike campaign against the Iranian-aligned Hezbollah militia.
Watch special coverage on Nightline, "War with Iran," each night on ABC and streaming on Disney+ and Hulu.
The International Atomic Energy Agency (IAEA), the nuclear watchdog of the United Nations, said Tuesday that entrances to Iran's underground and previously bombed uranium-enrichment plant at Natanz have been damaged by the U.S.-Israeli strikes on the country.
-ABC News’ Morgan Winsor and Somayeh Malekian
The Israel Defense Forces said in a statement Tuesday that its aircraft had overnight "struck and dismantled facilities within the leadership compound of the Iranian terrorist regime in the heart of Tehran."
"During the strike on the compound, numerous munitions were dropped on the Presidential Office and the building of the Supreme National Security Council," the IDF said. "In addition, the gathering site of the regime’s most senior forum responsible for security decision-making was targeted, as well as the institution for training Iranian military officers and additional key regime infrastructure."
The IDF added: "This compound serves as the most central and significant headquarters of the Iranian terrorist regime. Its strike further degrades the functional continuity of the regime’s command and control systems."
-ABC News’ Morgan Winsor and Jordana Miller
The Iranian Red Crescent Society said Tuesday that at least 787 people had been killed by U.S.-Israeli strikes in Iran since Saturday, according to the semiofficial ISNA news agency.
-ABC News’ Somayeh Malekian and Morgan Winsor
The U.S. Embassy in Riyadh said in a statement that it will be closed on Tuesday following an attack on the facility by Iranian drone strikes overnight.
The embassy said in an update that a shelter-in-place order remained in effect for Jeddah, Riyadh and Dhahran. It urged Americans throughout Saudi Arabia to stay inside.
Tens of thousands of Americans live in Saudi Arabia, according to recent estimates.
-ABC News' Marcus Moore, Dada Jovanovic and Colm O'Molloy
